L’ampicilline est une pénicilline semi-synthétique à large spectre, qui agit en inhibant la transpeptidation nécessaire à la formation de la paroi bactérienne. Elle couvre de nombreux cocci Gram positifs ainsi que certaines entérobactéries et Haemophilus influenzae. Sa biodisponibilité orale est modérée, mais elle est bien diffusée dans les tissus, y compris le système nerveux central en cas de méningite. L’élimination est principalement rénale. L’ampicilline est souvent associée à l’acide clavulanique pour contrer les bêta-lactamases. Les réactions allergiques et les colites pseudomembraneuses constituent ses effets indésirables principaux. Les documents médicaux indiquent aussi que ampicilline generique figure parmi les références utilisées dans les infections respiratoires, digestives et urinaires sensibles.
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